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I am very, very pleased with the Ruger 22/45 and will write as much here about it as I can. Keep in mind, however, that I've only fired about 400 rounds through it; certainly not enough to give a reliable review as to durability. Be aware that this is not an all-steel Ruger 22; the bottom half of the pistol is polymer. All of the working parts are steel.
For starters, the pistol is very nice to look at. I think the extra $32 is worth spending to have this model with the Cocobolo grips, as opposed to the molded plastic ones. The grips are well checkered, and provide a solid hold in the hand. As far as ergonomics go, I do agree that the "pointability" and "feel" are very similar to my 1911. The pistol comes up well on target, and seems to hold there naturally. The trigger is very good. Light and crisp. For the first 200 rounds or so it was sort of "scratchy", but that has gone away
It is a very, very accurate pistol. I have never had a .22 pistol before. Within 250 or so rounds, I was shooting the nails out of the frames, as well as very small target dots, on a seven yard target. It is not trick at all to keep your rounds on a pie plate-sized target at 50 yards, if you are that good of a pistol shooter. I can keep about half of them on from a two-hand grip. But if I use a padded rest, keeping the barrel steady, I can keep all of the rounds on the target at 50 yards. That is using Winchester white box .22 ammo. I will probably replace the sites at some point as, at 44, my eyes are not as good as they were several years ago and I feel that if I can improve my site picture, I think I could really do some really good shooting with this little pistol considering its accuracy.
I did not do any "break in" of the pistol. I just loaded it up out of the box, and started shooting. Of about 400 rounds, I have not had a single pistol malfunction. I don't think that's a large enough sample set to comment on durability as I said but, so far, so good. I did field strip the pistol this evening. IF you are careful, and IF you can follow directions--I just used the manual--I don't think you'll have any problems. The pistol IS more complicated to break down than, say, your Srpingfield XD 45. No question about that. But I did it, and I don't have especially dexterous hands or a mechanical engineering degree, so you can probably get it done, too. Just take your time, use a light coating of oil on the pistol parts after you've broken it down, DON'T "horse" it, and you'll find it's no problem.
As for any cons: the magazines seem very thin and flimsy to me. They appear to be made of stamped metal, and I can easily envision them bending or failing if you're not careful with them. I am going to look and see if I can find some stronger aftermarket mags at some point. Loading them seemed like a little bit of a pain as well. I already mentioned the field stripping: it won't stop me from buying another of these for my sons, down the road, but it does seem as though Ruger could have designed a better system in that regard.
That's about it for the pistol. Bud's was kind of slow in shipping it, and they explained that this was because they've reconfigured their warehouse situation. All to the good in the future, supposedly. It wasn't a problem for me. And as everyone states, their price beat the hell out of everyone else. On THAT basis alone, I'll continue to buy from Bud's, and just hope for faster shipping in the future.
My bottom line: BUY it, use it, learn it. You'll probably love it. I certainly do.