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Margaurite, these will fire ok but the 30 grain V-Max will be better in the 18 barrel as the Critical Defence is optimized for pistols shorter barrel.

YALL WILL HAVE A GOOD TIME WITH THESE. KEEP IN MIND THESE ARE SELF DEFENSE ROUNDS. THEY HAVE A HEFTY LITTLE PRICE TAG ON'EM YALL. I DONT KNOW BETTER OFF. I GUESS TRY'EM AND SEE IF YOUR RUGER LIKE'EM YALL. MUCH LOVE FROM TEXAS.

they will work just fine

These should shoot fine, just expensive.