BudsGunShop.com - Safe for S&W M&P 22 Compact?

Hi Michael, yes sir, these are safe for your M&P 22 Compact. Be aware that Use of hyper velocity ammunition in this pistol may affect wear characteristics and may result in the need for more frequent service and/or replacement of parts.
Stay safe & have a great day!

its safe but this is wat the owners manual says "Use of hyper-velocity ammunition in this pistol may affect wear
characteristics and may result in the need for more frequent service and/or replacement of parts:

Yes, as with the Aguila ammo, they would be safe to shoot out of your M&P compact but, like +P centerfire ammo you don't want to feed it a steady diet of Hyper velocity ammo as it may induce wear on internal parts in shorter intervals requiring more frequent maintenance/cleaning & possible repair/replacement of parts.