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Yes but you'll need the 22 mag cylinder

Hi Chris and welcome. Not through the 22lr cylinder. You will need a Heritage 22-magnum cylinder: https://shopheritagemfg.com/cylinders ----------- Cheers, stay safe and enjoy!

not as it comes for 22WMR you would need to purchase a 22 mag cylinder from Heritage https://shopheritagemfg.com/cylinders/heritage-22wmr-cylinder-6-shot-blued