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Hi Bryan and welcome. This will fit the Gen5 G21 no issue. Cheers, stay safe and enjoy!

Hi Bryan, this will fit the Gen 5, but model 078000552 is for the non-threaded barrel. The threaded barrel is 078000553, but they both have the same UPC 050806113145. I would contact Bud's to confirm whether or not this has a threaded barrel. 1-859-368-0371 9am-9pm EST Mon-Fri. or use the Blue Chat now button at the bottom right corner 9am to 8pm Mon - Fri Stay safe & have a great day!