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Hi Mike, see this thread >>> https://www.thefirearmsforum.com/threads/henry-big-boy-45lc-rifle.194360/

Hi Mike and welcome. Yes, .45 Schofield will fire but accuracy may be slightly diminished due to slight bullet jump to engage the rifling. Cheers, stay safe and enjoy!

Take Ed C.'s advice and view/read the thread he posted a link to. I read it myself, taught me something!!

Ed C posted a good thread I agree it may or may not feed and that can vary by individual rifles of the same model