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Yes. I did it. You will need to send them the frame for fitting unless you have a very good gunsmith that can do the work for you. m Get it from Taylor's.

Hi Adam and welcome. Yes, the new cylinder will likely need to be fitted for proper timing. I would contact Taylors Firearms for a possible .45ACP Cylinder: https://www.taylorsfirearms.com/1875-1890-cylinder-45acp-par-u0152005.html