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Hi Ivan and welcome. Not without milling of the cylinder and ejector star to make room for full moon clips that support .45 ACP cartridge cases. Some details here (just scroll down to Cylinder picture): https://www.americanrifleman.org/content/review-cylinder-slide-services-custom-ruger-super-redhawk/ ------- Cheers and stay safe!
Hi Ivan, not as is. From the factory, this particular gun can safely fire the hot .454 Casull cartridge, standard pressure .45 Colt rounds and .45 Colt +P loads which generate energy levels somewhere in between .44 Mag. and .454 Casull. However, the cylinder and ejector star can be milled, or lathed, to make room for full moon clips that support .45 ACP cartridge cases. Stay safe & have a great day!