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yes but you will need the proper mounting plate

Hi James and welcome. Yes, but you would need an RMR Adapter Plate to mount as the FUSE has an RMSc optics Cut. Cheers and stay safe!

It will, with the addition of an RMR adapter plate.

I say no, it's too wide for the thin slide of the P365 pistols. The Fuse, every other P365 uses the RMSc footprint for smaller optics. RomeoZero, 507K all mount directly to the slide.