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Hi Corey and welcome. No, the GP-100 is not drilled and tapped for scope mounts. However, Jack Weigand sells a full length Picatinny rail that mounts in place of the rear sight. --- https://www.jackweigand.com/Ruger-GP100-Scope-Mounts-No-Drill.html

Not drilled & tapped, but rail is available here >>> jackweigand.com/Ruger-GP100-Scope-Mounts-No-Drill.html Stay safe & have a great day!