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For a Mossberg Patriot .300 Win Mag bolt action rifle, the best ammo choice generally falls around 180-grain premium hunting bullets like those from brands like Hornady, Federal, or Winchester, with options like the Accubond or Power Max Bonded, depending on the game you're hunting and desired shot distance.

Hi Jonathan and welcome. For hunting, you will be hard pressed to find a better load than the Hornady Precision Hunter 178gr load: https://www.budsgunshop.com/product_info.php/products_id/115799/hornady+82041+precision+hunter+300+win+mag+178+gr+extremely+low+drag-expanding+20+bx+10+cs ------------ Cheers, stay safe and enjoy!