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Yes. 5.56mm NATO (223 REM)

Hi David and welcome. Normally for safety and warranty reasons, you should not fire 5.56 in a .223 stamped barrel. Since metallurgy has come a long way, I would get accurate information directly from Mossberg at (203) 230-5300 8AM-4:30PM EST or by online inquiry here: https://www.mossberg.com/contact-us

The information I provided was Directly from the Mossberg site for this model.

Hi David, Jason is correct, the MVP line of rifles is chambered in 5.56 and will fire both 5.56 and .223 Stay safe & have a great day!