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Hi Jeff and welcome. Yes Sir it would. These run at 1200 fps. Just as info, a 1250 fps 200gr load is here: https://ammowholesaleusa.com/shop-all/grizzly-ammunition-bear-load-10mm-200gr-fmj-fp/ ----------- Cheers and stay safe!

It would buuuut, you face the consequences of over penetration thus putting any targets outside of the 2 legged predator at risk. You'd be better off using a JHP round for self defense like the one below. https://www.budsgunshop.com/product_info.php/products_id/96691/sig+sauer+elite+v-crown+jacketed+hollow+point+10mm+ammo+180gr+20+round+box

Hi Jeff, it will incapacitate people if put where it needs to go. However, you're still much better off with modern JHP ammo. JHPs are much less likely to over penetrate and they create more substantial wounds leading to quicker incapacitation. budsgunshop.com/product_info.php/products_id/96691/sig+sauer+elite+v-crown+jacketed+hollow+point+10mm+ammo+180gr+20+round+box />. budsgunshop.com/product_info.php/products_id/1048/hornady+critical+duty+10mm+175+gr+20rd+box , . Stay safe & have a great day!

Yes, they will make that two legged predator dead as a doornail.