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Hi Brady and welcome. No Sir. For safety and warranty reasons, do not fire .45 Long Colt ammunition unless the firearm is specifically designed and marked as a combo gun that can safely chamber and fire both. Cheers and stay safe!
Absolutely Not!! The diameter of a .410 cartridge is smaller that that of a .45 LC. Unless the Firearm specifically states "can shoot both 45LC/.410" then NO!
Hi Brady, no sir, it would be unsafe. The standard bore diameter of a .410 is as expected 0.410 inches in diameter with constriction down to ~0.375 inches if your gun is choked about full choke. The 45 Colt is 0.451-.454 inches in diameter. That is significantly larger than the bore of a 410 shotgun it would be unsafe. In some cases, a .410 bore shotgun can be designed to also fire .45 Colt ammunition. This type of firearm is known as a "combination gun" or "combo gun." These firearms have barrels and chambers that are chambered for both .410 shotgun shells and .45 Colt cartridges. The key feature of these combo guns is a chamber that can accept both .410 shotgun shells and .45 Colt ammunition. The .45 Colt cartridges used in these firearms are typically longer than standard .410 shotgun shells, and the chamber is designed to accommodate both lengths. Stay safe & have a great day!