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Hi Bryan and welcome back. Most retailers have vague descriptions so I would get an accurate answer directly from SilencerCo Customer Service at 1 (801) 417-5384 or by online inquiry here: https://silencerco.com/contact-us/#:~:text=How%20Can%20We%20Help%3F,call%20801%2D417%2D5384.

Hi Bryan, per the Silencer Co web site, this does not fit the Glock 21 Gen 5 >>> https://silencerco.com/shop/threaded-barrel/ Stay safe & have a great day!

General consensus is a definitive No but...You can call SilencerCo Customer Service at 1 (801) 417-5384 and get a Proper answer.