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Hi Andy and welcome. The Ruger Mark IV 22/45 is a semi-automatic pistol chambered in .22 Long Rifle (.22LR) that features a grip frame designed to mimic the grip angle of a classic .45 ACP 1911 pistol, hence the "22/45" designation. The "22" refers to the caliber (0.22 LR), while the "45" alludes to the 1911's .45 ACP caliber and its grip angle. Cheers and stay safe!