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Hi Anthony, yes sir, they both use the Trijicon RMR footprint, so the Holosun HS507C X2 will be a direct mount to the M&P 2.0 .45 full size duty pistol. Stay safe & have a great day!

Yes sir, it appears that both have the same rmr footprint. It should mount up just fine. Happy shooting!

Absolutely yes, it uses the Trijicon RMR footprint so it'll be a direct fit!!

Good evening to you!! The Holosun HS507C X2 1x Red 2 MOA is an RMR footprint sight so it will be a direct fit mount to the M&P 2.0 .45 full size duty pistol. Hope this helps. Have a good rest of your day. 🇺🇸🇺🇸 'Merica' 🇺🇸🇺🇸

Hi Anthony and welcome. Yes Sir, the Holosun HS507C X2 1x Red 2 MOA is a direct fit. ***Note***, it is important to use a dab of blue Loctite to prevent screw loosening when firing to retail a consistent zero. Cheers, stay safe and enjoy!

Anthony Sir, YES, the Holosun HS507C X2 will fit by using one of the optics adapter plates that came with your pistol. The 507C X2 has a Trijicon RMR footprint, and the optics-ready M&P 2.0 models include a plate for this footprint. The optics-ready version of the M&P 2.0 .45 ships with multiple adapter plates, including one that fits the RMR footprint. To install the sight, you will remove the plate cover on your slide, attach the correct adapter plate, and then mount the Holosun sight to the plate. Hope the above information helps Anthony Sir, please take care and stay safe 🙏🏻

yes it fits without any issues