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Hi Dillon, For a Henry .45 Colt, a good starting load is typically around 250 grains for the bullet weight, using a powder charge of about 6.5 to 8 grains of Unique or 7 to 8 grains of Bullseye for standard loads. Always ensure that your loads conform to SAAMI specifications and consider experimenting to find what works best for your specific rifle. . Recommended Loads for Henry .45 Colt Bullet Weight Options Bullet Weight Type Purpose 230 grains Lead Flat Nose General use and target shooting 250 grains Lead Flat Nose Hunting and self-defense Powder Grain Recommendations Powder Type Recommended Grains Notes Unique 6.5 - 8.0 grains Versatile for various bullet weights Bullseye 5.0 - 7.0 grains Good for lighter loads . Stay safe & have a great day!