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Hi Richard, the only difference is the grips.
they are 2 different guns the 40149 is a Ruger IV 22/45 it is a polymer frame and uses a 1911 grip angle. The 40150 is a ruger MK IV is a alloy frames and uses a Luger grip angle. both are very guns
Richard, the 40149 is a "Polymer Framed" Pistol and weighs 33.3 Oz. & The 40150 is an "Aluminum framed" Pistol and weighs 34.6 Oz. The core upper receivers including barrels are the same.
they are 2 different guns the 40149 is a Ruger IV 22/45 it is a polymer frame and uses a 1911 grip angle. The 40150 is a ruger MK IV is a alloy frames and uses a Luger grip angle. both are very guns