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Joseph, 5.56 will be fine out of the Colt AR-15 Tactical Carbine. You can verify this with Colt Customer Service at Tel: 800-962-COLT (2658) *Mon-Fri 9am to 5pm EST

UPC crosses to a 5.56/ 223 gun so you will be fine specs Specifications and Features: Colt AR6720 Tactical Carbine 5.56x45mm NATO chamber (accepts .223 Remington) 16" Barrel 1:7" RH twist, 6 lands and grooves Gas operated, multi lug rotary locking bolt 30 Round magazine Forged flat top upper receiver Magpul MBUS folding rear sight Anodized aluminum upper/lower receivers Standard M4 front sight base Two-piece, black plastic handguards with heat shield Collapsible M4 stock 32" to 35.5" Overall length 5.98 lbs

Joseph, Absolutely this firearm will handle and is chambered in 5.56 NATO. With the 1:7 twist you can even stabilize some heavier grain rounds.