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Eric K. asked 7 years ago:
Eric, the model 8645 has no Manual Safety and model 8648 has an Ambidextrous Manual Safety. This is the only difference.
James G.
7 years ago
the 8645 has on thumb safety https://ruger.com/products/rugerAmericanPistol/specSheets/8645.html and the 8648 has a Ambidextrous thumb Safety https://ruger.com/products/rugerAmericanPistol/specSheets/8648.html
Randy I.
7 years ago