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Louis, No "ambidextrous" features. All the controls-slide stop, mag release, safety (if on that model) all on left side. Can shoot left handed, just a different manual of arms for a left hander.

Louis, with a little practice for familiarization, yes. There are some better options with "Ambidextrous controls though. Examples : https://www.budsgunshop.com/catalog/product_info.php/products_id/62288/Ruger+3314+SR9c+17%2B1+9mm+3.4 or https://www.budsgunshop.com/catalog/product_info.php/products_id/62290/Ruger+9MM+CMPT+3.5+ALLY%2FSS+3317

Lefties have shot right handed guns for years as a range gun you would have no problems for self defense that are better options I carry the SR9c and the SR40c https://www.budsgunshop.com/catalog/product_info.php/products_id/62288/Ruger+3314+SR9c+17%2B1+9mm+3.4