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I prefer #4 buckshot. It is enough to do the job, and cuts down on inadvertant over-penetration.

#4 Buckshot will reduce over penetration for possible family members and neighbors and still be very effective at home defense ranges. I use Nobel and it is excellent for this very scenario for home defense : https://www.budsgunshop.com/catalog/product_info.php/products_id/713073449/nobelsport_ammo_12ga_275