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Chris, yes Sir. This pistol has a "2 Position Frame Mounted Safety".

Chris, yes Sir. This pistol has a "2 Position Frame Mounted Manual Safety" as pictured here : https://www.google.com/search?q=beretta+21+bobcat+.22lr+matte+black&source=lnms&tbm=isch&sa=X&ved=0ahUKEwimp8bMqrLhAhVmleAKHUrgBbUQ_AUIDygC&biw=1280&bih=596#imgrc=_lt0uP0vqPneNM:

Chris - there is a safety .. and the slide does not lock open after the last round has been fired.