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Brett - Yes sir .. grips, slides, calibers .... all can be changed out. From SIG's Web site: The P320 Full-Size offers a smooth, crisp trigger to make any shooter more accurate, an intuitive, 3-point takedown and unmatched modularity to fit any shooter and any situation. Its full-size frame is ideal for target shooting, home defense and any scenario where shootability and sighted accuracy are of the highest priority. This modular, striker-fired pistol features a full-size grip, full length slide, and choice of contrast or SIGLITE Night Sights. Available calibers include 9mm, .357SIG, .40S&W and .45ACP. Safety features include a striker safety, disconnect safety.

Brett, Absolutely! All P320 have a removable, serialized, trigger group that can be put in any size 9mm or 40 S&W P320 frame. Simple. I have 2 trigger groups, 4 frames, and 3 different length slide and barrels in 9 and 40. 40 S&W magazines fit and function in 9mm also. Same magazine, 9mm magazine just has ribs in it to constrict interior.

yes you are correct the serialized part is the lift out trigger assy here is a good review https://www.thetruthaboutguns.com/2014/05/foghorn/gun-review-sig-sauer-p320/

This is a 10 - 4 Brett. This has the adaptable "Modular" Frame Sir.