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it will depend on what you are going to customize I suggest that you shoot it enough in the stock configuration to know it is 100% reliable then do one mod or customization at a time verifying that the gun function is still 100% before the next change

Douglas, depends on your modifications. Most issues arise out of too much "Slide Weight" added by certain accessories they may throw your balanced cycling off. Frame mods have less effect so just pay attention to your slide and you should be fine.