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yes you can it has a Safety: Ambidextrous Manual Safety see *******UPC: 723364200236 Description: WAI PK380 DA 380 8R 3.6 B/N Brand: Walther Arms Inc Model: PK380 Type: Pistol: Semi-Auto Caliber: 380 Finish: Black W/ Nickel Slide Action: Double Action Stock: Black Polymer Sight: FT: 1-Dot RR: 2-Dot Barrel Length: 3.66 Overall Length: 6.5 Weight: 19.4 oz Capacity: 8+1 # of Mags: 1 Safety: Ambidextrous Manual Safety Receiver: Black Polymer, Picatinny Style Accessory Rail Features: External Hammer; *******Ambidextrous Magazine Release

Robert, you should have no issue with the Ambidextrous Manual Safety & Magazine Release Levers. This Pistol is very Lefty Friendly Sir.