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Well, that will be a personal preference. This topic is subjective. I love .22lr, but I really like that .25 ACP is centerfire. There have been many comparisons with these two rounds. Paul Harrell on YouTube has a great video on this. Here's the link: https://m.youtube.com/watch?v=nnnJ0vjXQmo

I think the reliability of Centerfire is better than the reliability of Rimfire. With that alone I will choose a Centerfire for concealed carry.

Hands down you have to go with the centerfire caliber even the small 25 bro. Just my two cents,