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Michael, yes Sir. This model will accept Drum Magazines no issue.

This will definitely work with a drum magazine chambered in 45 ACP. It was my pleasure to assist you. Happy Thanksgiving.

Michael, Yes this firearm will function with drum magazine. Here is the 100 round drum from Auto Ordnance-------https://www.budsgunshop.com/product_info.php/products_id/712002918/ao+mag+thompson+1927a1+45acp+100rd+drum