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Gary, this will depend on the bullet design of your 150gr load. I would try a few 150gr loads to see which yields the best accuracy and then stock up. I would start with a 200yd zero as most rifle bullets go to sleep by that range (stabilize).

Gary, I would always start with a 100 yard zero on any rifle and work your way out. Velocity sweet spot is 3000 to 3300 fps at the muzzle with a 150 grain bullet. This Federal Fusion round is right there.-Federal F270WSMFS1 Fusion 270 Winchester Short Magnum (WSM) 150 GR Fusion - Muzzle Energy, 3119 ft lbs. Muzzle Velocity, 3060 fps. It will still have enough oomph out to 800 yards plus. With hand loads it is difficult to exceed .300WSM factory velocities by any great amount. The .300 WSM achieves top velocities with powders in the 4350, ADI 2209 medium/slow burning range while some rifles achieve better results with slower burning powders in the H4831sc, N165, RE22, ADI 2213sc range, requiring experimentation for best results. From a 24" barrel typical velocities include 3500fps with 130 grain bullets, 3300fps with 150 grain bullets, 3100fps with 165-168 grain bullets, 3000fps with 180 grain bullets, 2800fps with 200 grain bullets, 2700fps with 208-210 grain bullets and 2600fps wi