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Larry, probably but, I would verify with Henry Sir for warranty and safety reasons at Tele: 201-858-4400. Some info on Buffalo Bore here : https://www.ammoland.com/2014/11/henry-big-boy/#axzz69GDHkIJ7

I've used many hot 44 magnums rounds in my Henry but never used 44 +P only because that's not what my Henry is advertised to do. James is correct. I would contact Henry to get their input. It was my pleasure to assist you.

Larry, I wouldn't use this +P round in my Henry. Plenty of 44 mag rounds that will harvest a whitetail without chancing damaging you or your rifle.

I also agree check with Henry before using them Tele: 201-858-4400