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John, I would gather this information directly from Ruger Customer Service for accuracy at Telephone: 336-949-5200 (Monday through Friday 8:00am - 6:00pm ET).

the charging handle and the mag release are reversible but the crossbolt safety is not see page 21 of the owners manual https://ruger-docs.s3.amazonaws.com/_manuals/PC-Carbine_Chassis.pdf