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For home and self defense #4 birdshot. Wont penetrate your walls as bad as #4buckshot. If you are hunting with this, then food is not available. Slugs, and hunt deer. You will not get to aim, so practice.
Tierney, I would recommend Number 4 Buckshot. It has the best balance of stopping power with out over penetration : https://www.budsgunshop.com/product_info.php/products_id/411559297/rio+royal+buck+%234+buck+12ga+27+pellet+5+pack+2+3%2f4 ------- You should watch this video in it's entirety : -- https://www.youtube.com/watch?v=rhZf_x8Esms
Personally, I use different ammunitions in my home defense shotgun. My first 2 shots are less than lethal bean bags. Followed by that are 4 #6 birdshot. Birdshot will not penetrate walls. The likelihood of a slug or 00 buckshot going through different objects are higher compared to a birdshot. That's my preference. Use what you train with the most. Try out different kinds of ammunition and find one you like. It was my pleasure to assist you.