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Frank, Absolutely. Take the flash hider off and this silencer will screw right on.

Lightweight, compact sound suppressor designed for any threaded-barrel rimfire host, pistol or rifle. Combination of a titanium tube, stainless steel muzzle mount, stainless steel baffles and aluminum rear cap. Black Cerakote finish. 1/2-28 threads. Supported calibers: .22LR, .22WMR, .17HMR. 5.375 Inches, 6.3 Ounces, 1/2-28 Threads, Black Cerakote Finish As long as the thread is 1/2-28 thread. Then you can mount it on any 22. The Smith & Wesson M&P15-22 comes with a standard 1/2-28 thread. tacticool makes adapters if needed, but as long as your came with a flash suppressor then you shouldn't even have to futz with it

Frank, yes Sir you can. The MP 15-22 has 1/2-28 Threads so this is a direct attachment suppressor. Cheers and stay safe!