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Thomas, no Sir. Just 22Magnum. 22LR would require a different cylinder as the 22LR would be too loosey goosey in the 22 Magnum Cylinder. It is precisely why Combo 22M/22LR revolvers come with two cylinders.

No the 22LR and 22WMR aren't interchangable the 22Mag has a larger diameter and you will destroy the i side of the barrel. Watch this video here and it shows not just the loss of velocity but watch till the end when he shows the swollen cases and from the 22lr and talks about the metal shaving coming out of the barrel. https://youtu.be/1ubQlgMqhF8

Thomas, This wheel gun will not fire 22 lr