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William, Ruger does not state if this is +P rated in the manual. (https://ruger.com/products/vaqueroStainless/specSheets/5105.html) - For safety and warranty reasons I would confirm directly with Ruger Customer Service at Telephone: 336-949-5200 (Monday through Friday 8:00am - 5:00pm ET)

William, All the Ruger revolvers are built like tanks. I would not hesitate to fire +P ammo in this handgun. Ruger is one of the stoutest wheel guns on the market.