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Yes seperate cylinders are required, as the 22Lr and 22Wm are different size and pressure cartridges, not all 22 Lr have a 22Wm cylinder available and not all 22Wm have an available 22lr cylinder l, but some revolvers come with both.
they require different cylinders as the 22WMR has a fatter case and will not fit in a 22lr cylinder. If you fire a 22lr in a 22WMR cylinder the case could rupture (to loose and not supported) causing a unsafe condition
The two cylinders are not interchangeable. You must use the proper cylinder to shoot only the cartridge it was designed for..
Charles, two separate Cylinders have always been required due to significant case size difference which would be unsafe attempting to fire 22LR from a 22Mag Cylinder. 22Mag will not fit in a 22LR Cylinder. It is the reason all dual caliber combo pistols come with (2) Cylinders : https://www.budsgunshop.com/product_info.php/products_id/87939/heritage+manufacturing+srr22mbs4+rough+rider+6rd+22lr%2f22mag+475%22+steel+frame
