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Gary, it would require a barrel with a Fully Supported Chamber, stronger recoil spring etc. Even then a .45ACP designed pistol is designed for the much lower pressure 45ACP. This factors into safety and warranty issues. Some great details here on the differences : https://skyaboveus.com/hunting-shooting/What-is-the-45-Super

YES, but it requires extensive conversion and only works on certain pistols. For more info Check HERE ( http://www.45super.com/ ). You are better off getting .45 Super instead of trying to convert it. I hope this helps

Gary, Yea you can turn a Honda into a rocket ship. Yea you can, but it takes some money, parts, good gunsmithing.