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NO, unfortunately, the 22 mag frame CANNOT handle the recoil of 380cal.,9mm, or a 38. Moreover, the 22 mag is rimfire ammo, it needs to be converted to centerfire in order to shoot the above cartridges. Your only option is to get a dedicated 380cal.,9mm, or a 38 Derringer. I hope this helps

James, no Sir but Cobra used to sell a rimfire/centerfire conversion kit. Set includes .22 Long Rifle, .22 Magnum, .25 Auto and .32 Auto caliber barrels.. The conversion kits are hard to find though : https://gun.deals/product/cob-std-22lr22mag2532-24-289

No not interchangeable, to many differences, centerfire vs rimfire, 30cal vs 22 cal. But buds has the 380 Derringer in stock here and its only $145 https://www.budsgunshop.com/product_info.php/products_id/415012580