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Not sure about the 4.25" barrel length but it will not work with the M2.0 "Fits: For standard M&P Frame with NO magazine safety Note: Not Compatible with new M&P M2.0"

Looks like they make a separate slide kit for the 4.25" model but this one is also not compatible with the 2.0 https://outdoors.natchezss.com/bestsellers/M%26p-Slide-Kit

Adam, unfortunately no Sir. Fits: the standard M&P Frame with NO magazine safety. ***Note***: Not Compatible with new M&P M2.0.