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Marco, no Sir. Details on page 10 here : https://img1.wsimg.com/blobby/go/6c343e9c-bf53-489b-8df0-269a38fb7b50/downloads/BigBoreDerringer-Manual.pdf?ver=1602192091499

NO, according to user manual ", DO NOT use (+P) loads in any Cobra Enterprises manufactured Derringer." I also do not recommend this gun, the trigger is very very b a d. I hope this helps!