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Smith & Wesson M&P15-22 Pistol grip is small and would work fine for your wife. If not, you can change the grip on it since it works with any AR 15 grip. I hope this helps!

Jack, the M&P15-22 Pistol grip works with a wide range of hand sizes including small hands. Also the same for the Kel-tec : https://www.budsgunshop.com/product_info.php/products_id/111461/kel-tec+cnc+cp33blk+cp33+22+lr+semi-automatic+55+33%2b1+black+ -- Cheers and stay safe!

Yes the M&P is a great choice and is in stock here https://gun.deals/search/apachesolr_search/022188083903 ------------------- The ruger SR22 https://www.budsgunshop.com/product_info.php/products_id/712018423 ---------- The Walther P22Q https://www.budsgunshop.com/product_info.php/products_id/111597 ------------ And the Ruger LCPII https://www.budsgunshop.com/product_info.php/products_id/132417 ----------------- Taurus TX22 https://www.nwarmory.com/product/product-tau-1tx22141 ----------------- Are good options too. You can also use handgun hero to compare size and features. The Walther p22Q has a smaller grip in every over the MP http://www.handgunhero.com/compare/walther-p22-q-vs-smith-wesson-m-p-22-compact