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Timothy, this is designed for Large frame pistols and would be slightly large for the S&W M&P45 Compact. I would highly recommend a specific fit Alien Gear IWB Holster : https://aliengearholsters.com/holsters/s-w-m-p45c-compact-4-inch-barrel.html

The holster will be to large for it. Many other companies offer great selections. Myself, I use ANR desgin IWB holsters.

No it won't due to the compact frame. This holster is for full-size handguns. I recommend alien gear or Tulster for your holster needs. Stay safe and happy plinking!!

This is for larger framed pistols. The S&W 45 compact would be to small to fit properly. Sorry but hope this helps.