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No, this is just 223/5.56 and cannot shoot 300 black out. my radical firearms pistol came with a multi-caliber lower Wich means you could swap this upper with a 300blk upper and shoot both but you'd have to buy a complete upper for this and swap them back and forth to shoot both calibers. Hope this helps.

Carlos, no this is 5.56/.223. Do not try to shoot 300 blackout from this gun, that is a completely different caliber.

Carlos, this rifle shoots just 5.56/.223 with the current upper. You can certainly purchase a 300BLK Upper and shoot 300 BLK as well. 5.56/.223 is 22 caliber and 300 BLK is 30 Caliber requiring an entirely different upper. Cheers and stay safe!

You could if you swapped the upper, or the barrel, and the muzzle device. It's easier to just have 2 separate uppers, as then you can switch between the calibers by popping 2 pins, if you went the changing the barrel and muzzle device route that you'd likely want to be permanent or at least semi permanent, as everytime you swap the barrel, you need to torque it to the correct ppi, and check the barre/ chamber head space, much easier to just have 2 uppers or change it once and leave it ( if swapping barrels)