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No, not recommended. This design is not intended for hotter than normal ammo.

I wouldn't recommend it. This is open top design and meant more for standard pressure/velocity ammo. Hotter loads could cause complications. Hope this helps.

Garrett, unfortunately no Sir. Uberti does not recommend +P ammunition for both warranty and safety reasons. Cheers and stay safe!

Garrett, no, taken from owners manual -- "ammunition marked "High speed" or "High velocity," or cartridges of an incorrect caliber, can cause excessively high chamber pressures resulting in severe damage to your firearm".

No these are made as a range toy not a serious working/ hunting gun