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YES, P320 is a modular pistol and the serialized part (the actual firearm) is the trigger group. This means you can change up anything. I have one with compact frame but with a full-size slide and barrel. However, the full size slide on subcompact frame leaves a gap between the front end of the frame and the dust cover on the bottom of the slide. I hope this helps!

As mentioned below. Personally I'm not a fan of longer slides on subcompact frames...