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Kevin, should work with no problem however, I wound confirm this with Ruger Customer Service at Telephone: 336-949-52000 - (Monday through Friday 8:00am - 5:00pm ET)
Kevin, no, the Mark IV and the Mark IV 22/45 magazines are not interchangeable. You can convert your Mark IV mags to work on the 22/45 with this magazine block bottom >>> https://shopruger.com/Mark-III-Magazine-Block-Bottom/productinfo/61097/ .....Have a great day!
Kevin, no, the Mark IV and the Mark IV 22/45 magazines are not interchangeable. You can convert your Mark IV mags to work on the 22/45 with this magazine block bottom >>> https://shopruger.com/Mark-III-Magazine-Block-Bottom/productinfo/61097/ .....or this one >>> https://store.wirthweinguns.com/Ruger-Magazine-90599-Base-Block-22-45-MK-p/r-mk-magp-bse-2245-mk4.htm .....Have a great day!