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Joseph, these will work great in the Smith and Wesson Shield 2.0 in .45ACP. Another highly recommended self defense load in the Hornady Critical Defense Load : https://www.budsgunshop.com/product_info.php/products_id/61043/hornady+critical+defense+45+acp+185gr+20rd+box

Yes, this will work great in your smith and Wesson. This is a great self defense round. Hope this helps.

Joseph, this will work just fine in your S&W Shield. Have a great day!