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It has a Manual Thumb Safety but it is located on the left side only as pictured here : https://redriverrange.com/product/phoenix-arms-hp2anb-hp-22-lr-3-101-nickel-black-polymer-grip#product_detail

It has a thumb safety, but it is not ambidextrous. Located on left for right handed shooters. Have a great day!

This does have a thumb safety but it's on the left side for right hand shooters. It's not ambidextrous. Hope this helps.