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Christopher, absolute top tier for this situation is the 9mm or .380 Shield EZ Series handguns. Excellent details here : https://www.youtube.com/watch?v=ZDSeQy7ach0

Revolver is fine but you are looking at relatively heavy trigger pull and very low ammunition capacity. Is your wife planning on conceal carrying this pistol or just home defense (sitting in a drawer/safe). With (some) semi-auto pistol, you will benefit from better trigger and much more ammo capacity. I also noticed that it is much easier to teach someone to handle semi auto gun than revolver. The S&W 380 Shield EZ is even easier to handle than the 9mm EZ. Both are worth looking at for those with arthritis when come to semi-auto pistol. The SW 380 Shield EZ can be have for less than $350 HERE ( https://gun.deals/search/apachesolr_search/022188872934 ). Make sure that it has "EZ" on it and not just normal Shield. Also, some version has thumb safety too, so take note of that (Standard Shield EZ has grip safety which is more than suffice in my opinion). I also wanted to point out that there are companies making slide rack assist for all sorts of semi-auto handguns. I have Recover tactica

Christopher, I'd recommend the Walther ccp m2 in 380 acp. it's rated one of the best pistols for people with arthritis. Here is a link to one if interested........... https://www.budsgunshop.com/product_info.php/products_id/105497/walther+arms+ccp+m2+.380+acp+bk+bk+3.54+8+1................ Revolvers are good but alot of revolvers are made of all steel Wich can make them really heavy. So if you go with a revolver I'd go with something like the charter arms undercover lite Wich is designed to be light. Here's a link to that if you decide to go with a revolver. Hope this helps and good luck with your choice, link here................ https://www.budsgunshop.com/product_info.php/products_id/48450/charter+arms+53820+undercover+lite+standard+single+double+action+.38+spc+2+5+black

Sorry but this NOT the type of question to be asking online. You need to physically have her try a handgun at a local gun shop or firing range. NO ONE person is the same NONE! Opinions (no offense to the other posters) are sorry to say near useless in these cases. Again many gun shops deal with this all time and would be glad to find a gun to fit her needs or disability and it will be the EXACT FIT. Good luck!